multi drug resistant gram-negative bacteria infection in Lung transplantation recipients
Conditions
Interventions
exposure group:Ceftazidime/avibactam
non exposure group: polymyxin
Sponsors
The Affiliated Wuxi People's Hospital of Nanjing Medical
University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: ? Male or female 18 years and older. ?Diagnosed with pulmonary infection induced by multidrug resistant gram-negative bacteria (MDR-GNB) Pathogenic est combined with clinical manifestations, and testing, and treatment with CAZ/AVI or polymyxin for = 3 days ?Informed consent is acceptable and signed by the patient or authorized persons.
Exclusion criteria
Exclusion criteria: ? Age<18 years old; ? Patients received CAZ/AVI or polymyxin treatment <3 days; ? MDR-GNBs colonization or contamination; ? Allergic or intolerant to CAZ/AVI or polymyxin ;? Bloodstream infections associated with MDR GNBs; ? In addition to infectious diseases, other diseases affect patients’ lives in the short term , such as Pulmonary embolism, acute myocardial infarction, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day mortality rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 14 -day clinical therapy failure rate;21 -day clinical therapy failure rate;14 -day microbial clearance failure rate;21- day microbial clearance failure rate; 60 -day mortality rate; | — |
Countries
China
Contacts
Public ContactXiuhong Zhang
University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University
Outcome results
None listed