precocious puberty
Conditions
Interventions
Non-exposed group of Simple Premature Thelarche:NA
Exposure group of Simple Premature Thelarche (Only accept the intervention of Jiuwei chushi Granules):NA
Depherelin Group of Central Precocious Puberty (Only accept Depherelin intervention):NA
Jiuwei chushi Granules Group of Central Precocious Puberty (Only accept the intervention of Jiuwei chushi Granules):NA
Sponsors
Hubei Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Age
4 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1. The child meets the diagnostic criteria of western medicine for precocious puberty (Simple Premature Thelarche or central precocious puberty); 2. The child meets the TCM diagnostic criteria of mainly Yin deficiency and fire and liver stagnation and fire; 3. Children are only girls, aged =4 years and =10 years old; 4. The child has not received any treatment before, which is consistent with the first diagnosis; 5. The children themselves and their legal guardians have informed consent and cooperated with this study.
Exclusion criteria
Exclusion criteria: 1. The child has menarche; 2. Peripheral precocious puberty; 3. Incomplete precocious puberty except Simple Premature Thelarche; 4. Central precocious puberty caused by primary hypothyroidism; 5. Central precocious puberty caused by organic diseases of the central nervous system, such as hypothalamic and pituitary tumors, hamartoma, hydrocephalus and trauma; 6. TCM diagnosis of precocious puberty (mainly Yin deficiency and fire and liver stagnation and fire) and other syndromes; 7. Accompanied by serious diseases of heart, kidney, liver and hematopoietic system; 8. Those who are highly allergic or allergic to the drugs in this study; 9. Those who have recently participated in other clinical trials and affected the judgment of curative effect or have recently used sex hormone drugs or traditional Chinese medicine.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Staging of breast pain;Stages of pubic hair development;Staging of vaginal discharge;TCM syndrome score;Breast volume;Uterine length;Ovarian volume;Sex hormone six;growth rate;Bone age index;CBCL psychological scale score;IGF-1;IGFBP-3;routine blood test;Urine routine;Then routine;Liver and kidney function ;fasting blood-glucose;Thyroid function;VitD;electrocardiogram; | — |
Primary
| Measure | Time frame |
|---|---|
| Staging of breast development;Incidence rate of adverse events; | — |
Countries
China
Contacts
Public ContactJIANZHONG LIU
Hubei Provincial Hospital of Traditional Chinese Medicine (Affiliated Hospital of Hubei University of Traditional Chinese Medicine)
Outcome results
None listed