plaque, gum disease,
Conditions
Interventions
Test:BOP toothpaste containing antimicrobial peptides
Control group:Control toothpaste with active ingredients removed
Sponsors
Ethics Committee of Shandong University Stomatological Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: A) aged from 18 to 65 years old, with good general health and no serious systemic diseases; B) have more than 20 detectable teeth with an appropriate degree of bacterial or gingivitis, and at least 1 tooth with dentin sensitivity, sensitive to tactile stimulation of 10g~50g, and/or cold air stimulation; C) Agree not to use any non-test toothpaste during the test; D) No eating garlic, leeks, stinky tofu and other dietary habits that are prone to oral odor; E) Maintain good hygiene and brush your teeth twice a day; F) The halitrosis index (the mean value of 3 measurements by breath instrument) is =125 when checked by breath detector; G) No use of the following drugs: anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, or antibiotics in the month prior to study entry; H) Signed informed consent form.
Exclusion criteria
Exclusion criteria: A) Participation in other clinical studies; B) Use phenolic or mint flavoured products on the same day, such as non-test toothpaste, gum, etc. C) Have a history of allergy to this product and its ingredients; D) suffering from AIDS, insulin-dependent diabetes mellitus, receiving anticancer chemotherapy within 6 months, immune deficiency, autoimmune diseases or other serious diseases; E) For patients with severe gingivitis, periodontitis or oral ulcers, partial or full dentures should be worn; F) smoking or using tobacco products; G) The presence of any diseases and conditions that the trial investigator believes may affect the procedure of the examination and the safe completion of the trial; H) Women in pregnancy, lactation and menstruation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plaque index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding on Probing;Dental calculus index;The effectiveness index of tooth sensitivity;Validity index of breath test;Security Index; | — |
Countries
China
Contacts
Public ContactMi Du
Hospital of Stomatology, Shandong University
Outcome results
None listed