Acute and chronic renal failure
Conditions
Interventions
experimental group:HDF180 hollow fiber hemodialysis filter
control group:FX800HDF hollow fiber hemodialysis/filter
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients with maintenance hemodialysis of chronic renal failure who have received hemodialysis treatment for more than 3 months; (2) 18 years old= age = 80 years old, gender is not limited; (3) Patients with regular hemodialysis, dialysis 2-3 times a week; (4) It can ensure that the blood flow during hemodialysis is not less than 200mL/min; (5) Patients with autologous arteriovenous fistula with vascular access; The subject or his/her guardian was able to understand the purpose of the study, voluntarily participate and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients who received any kind of blood purification treatment, including hemodialysis (HD), hemofiltration (HF), hemodiafiltration (HDF), hemoperfusion (HP), continuous renal replacement therapy (CRRT), etc., within 24 hours before the test was put on the machine, and had an impact on the evaluation of the trial; (2) Patients with severe anemia (hemoglobin content < 60g/L); (3) Patients with severe liver disease (alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =3 times the upper limit of normal); (4) Have severe neurological diseases, myocardial infarction, severe myocardial lesions and refractory heart failure or NYHA grade 4 within 1 month before enrollment; (5) Severe hypertension (controlled systolic blood pressure = 180mmHg or diastolic blood pressure =110mmHg) before diastolen); (6) Combined with intracranial hemorrhage or increased intracranial pressure, severe shock that is difficult to correct with drugs, systemic infection or uncontrolled local infection, history of AIDS or syphilis, active malignant tumor, active tuberculosis or failure of other important organs other than kidneys; (7) Patients with hemodialysis combined with peritoneal dialysis; (8) Patients with psychiatric diseases or medical history; (9) Patients with low weight (< 40kg); (10) Those who have participated in other clinical trials within 1 month; (11) Those with a history of polysulfone allergy, and those with a history of previous allergy to extracorporeal circulation pipelines and filters; (12) pregnant and lactating women; (13) Those who the investigator believes are not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ß 2-microglobulin;creatinine;Urea nitrogen; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood electrolyte;liver function;CRP;Blood gas; | — |
Countries
China
Contacts
Public ContactNian song Wang
Shanghai Sixth People's Hospital
Outcome results
None listed