The use of hemodynamic management under the guidance of cerebral oxygenation to improve postoperative outcomes in elderly and high-risk patients with hip replacement: a randomized controlled trial

The use of hemodynamic management under the guidance of cerebral oxygenation to improve postoperative outcomes in elderly and high-risk patients with hip replacement

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300074989

Enrollment

Unknown

Registered

2023-08-22

Start date

2023-09-01

Completion date

Unknown

Last updated

2023-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hip disease

Interventions

Control group:Through invasive hemodynamic monitoring, the target is to maintain MAP =65 mmHg through the standard process.

Intervention Group:With an rSO2-oriented hemodynamic management strategy, the target is to maintain rSO2 =90% of the baseline value and MAP =65 mmHg through the standard process

Eligibility

Sex/Gender

All

Age

80 Years to 100 Years

Inclusion criteria

Inclusion criteria: Elderly (=80 years old) patients undergoing elective hip surgery under general anesthesia had three or more of the following factors: 1. History of cerebral infarction or transient ischemic attack, 2. Hypertension, 3. Diabetes, 4. Renal insufficiency, 5. Smoking, 6. Chronic obstructive pulmonary disease, 7. Cardiovascular disease (peripheral arterial disease, coronary heart disease, heart failure), 8. Carotid artery stenosis (especially the symptomatic type), 9. Obesity or hyperlipidemia.

Exclusion criteria

Exclusion criteria: 1. Emergency surgery; 2.Recent myocardial infarction or cerebral infarction (within 3 months);3.patients with severe systemic disease who cannot tolerate surgical anesthesia;4.Severe uncontrolled hypertension with systolic blood pressure (SBP) >= 180 mm Hg or diastolic blood pressure (DBP) >= 110 mm Hg; 5.Psychiatric diseases;6.Inability to undergo neuropsychological assessments due to severe visual or hearing impairment or intellectual disability. Known cognitive impairment, the score of MMSE<24.7.ASA grades is ?-?. 8. Refuse to participate.

Design outcomes

Primary

Measure	Time frame
cognitive function;	—

Secondary

Measure	Time frame
Postoperative rehabilitation (anesthesia recovery time?time to recovery of bowel function);length of stay (LOS) in hospital;regional cerebral oxygen saturation (rSO2 ) ;Intraoperative monitoring index(MAP,HR,SPO2);depth of anesthesia;S100ß protein;Neuron specific enolase;matrix metalloproteinase,MMP;	—

Countries

China

Contacts

Public Contacttuwenlong

Jinhua Hospital Affiliated to Zhejiang University

jhyy813@163.com+86 135 8697 6895

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026