hepatic encephalopathy
Conditions
Interventions
NHE:NA
CHE:NA
OHE:NA
Sponsors
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) NHE group inclusion criteria: Liver cirrhosis patients =18 years old with normal blood ammonia; West-Haven classification level 0, normal neurological signs, normal neuropsychological tests; The patient agrees to participate and signs the informed consent form. (2) CHE group inclusion criteria: Liver cirrhosis patients =18 years old with elevated blood ammonia; Subclinical hepatic encephalopathy and West-Haven classification Class 0, Class I HE, with no personality or behavioral changes or with mild clinical signs (such as mild cognitive impairment, attentional impairment, sleep disturbance, euphoria, or depression); Normal nervous system signs/flapping wing tremor can induce, abnormal neuropsychological tests; The patient agrees to participate and signs the informed consent form. (3) OHE inclusion criteria: Liver cirrhosis patients =18 years old with elevated blood ammonia; Mental abnormalities such as personality and behavior changes, coma and other neurological abnormalities, West-Haven classification 2~4 HE; Positive neurological signs such as ankle clonus; The patient's legal guardian agrees to participate and signs the informed consent.
Exclusion criteria
Exclusion criteria: (1) With malignant tumor; (2) With a history of malignant tumor treatment; (3) Complicated with serious heart, lung, brain, kidney disease or severe diabetic complications; (4) Antibiotics, prebiotics, probiotics and proton pump inhibitors have been used within three months; (5) Pregnancy or puerperium.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proteomic data analysis(YNMT)· ;Microbiome nucleic acid analysis; | — |
Countries
China
Contacts
Public ContactWenfang Cheng
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital)
Outcome results
None listed