cervical cancer
Conditions
Interventions
Sponsors
the First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
Female
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients diagnosed with cervical cancer (2018 FIGO staging) I, II, III, and IVA by pathology; (2) Aged 20 to 75 years old; (3) The general condition of the patient is good, no obvious symptoms, KPS > 70 points; (4) RTOG Independent Recursive Grading Index (RPA) = 2; life expectancy = 6 months; (5) The function of each organ is basically normal (in the absence of continuous supportive treatment, laboratory test results within 1 week before enrollment): neutrophils>1.5×109/L, platelets>100×109/L , hemoglobin > 9.0g/dl; bilirubin normal or <1.5×ULN; AST(SGOT), ALT(SGPT) <2.5×ULN (<5×ULN if liver metastases); serum creatinine <1.5×ULN; (6) Have not received pelvic local radiation therapy before enrollment, and voluntarily received radiation therapy for cervical cancer. (7) Fully introduce the research content to the patients who meet the screening criteria, and ensure that the patients have fully understood the research and voluntarily signed a written informed consent form before any research-related procedures start.
Exclusion criteria
Exclusion criteria: (1) Previously received pelvic local radiotherapy; (2) The general condition is poor, KPS<70 points; (3) RTOG Independent Recursive Grading Index (RPA) = 3; (4) Pregnant patients; (5) Patients with severe, uncontrolled organic disease or infection, such as decompensated heart, lung, or renal failure, who cannot tolerate radiotherapy, targeted therapy, or chemotherapy; (6) Second primary tumor; (7) Major surgery within 4 weeks of trial randomization; (8) Allergic constitution, such as those with a history of allergy to two or more drugs or food; or those who are known to be allergic to the ingredients of this medicine; (9) Factors considered by other researchers to be inappropriate to participate in the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OS;PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of side effects of radiotherapy; | — |
Countries
China
Contacts
Public ContactJu-ying Zhou
the First Affiliated Hospital of Soochow University
Outcome results
None listed