FindTrial
Sign In

Dose-effect relationship of sedative effect of different loading doses of dexmedetomidine combined with retromammary space anesthesia in minimally invasive breast surgery

Dose-effect relationship of sedative effect of different loading doses of dexmedetomidine combined with retromammary space anesthesia in minimally invasive breast surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300074954
Enrollment
Unknown
Registered
2023-08-21
Start date
2023-09-01
Completion date
Unknown
Last updated
2023-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple solid breast masses

Interventions

Control group ( group C ):Intravenous load of 0.5ml / kg normal saline, pumping time of 5 minutes, 5 minutes after the end of the load line after breast space anesthesia, and then began minimally inva
Study group 1 ( D1 group ) :Intravenous load of 0.5ug / kg dexmedetomidine, pump injection time of 5 minutes, 5 minutes after the end of the load line after breast space anesthesia, and then began min
Study group 2 ( D2 group ):Intravenous loading dose of 0.75 ug / kg dexmedetomidine, pump injection time of 5 minutes, 5 minutes after the end of the loading dose of retromammary space anesthesia, and
Study group 3 ( D3 group ):Intravenous load of 1.0 ug / kg dexmedetomidine, pump injection time of 5 minutes, 5 minutes after the end of the load line after breast space anesthesia, and then began min

Sponsors

Shaoxing Shangyu Maternal and Child Health Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: ( 1 ) Female patients who need to undergo minimally invasive breast surgery for the diagnosis of multiple solid breast masses ; ( 2 ) 20 to 60 years old ; ( 3 ) ASA ( American Society of Anesthesiologists ) grade I, II ; ( 4 ) Informed consent was obtained according to GCP.

Exclusion criteria

Exclusion criteria: ( 1 ) Have a history of heart block, hypertension, upper respiratory tract infection, asthma, liver and kidney dysfunction ; ( 2 ) Dexmedetomidine or lidocaine allergy history ; ( 3 ) History of memory or cognitive impairment, lack of understanding of the consent process ; ( 4 ) At the same time the application of ß-blockers, drug or alcohol abuse history.

Design outcomes

Primary

MeasureTime frame
ramsay sedation score;—

Secondary

MeasureTime frame
MAP;HR;SpO2;Visual Analogue Scale ( VAS ) score;Number of cases with pain score = 3 points;—

Countries

China

Contacts

Public ContactChen Jianxiao

Shaoxing Shangyu Maternal and Child Health Hospital

2756333089@qq.com+86 153 2523 8739

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026