open fracture
Conditions
Interventions
intervention group:EDTA-NS irrigation group
control group:NS irrigation group
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Male or female patients over 18 years of age; (2) open fractures (Gustilo-Anderson I-IIIB); (3) Patients who are able to sign informed consent on their own;
Exclusion criteria
Exclusion criteria: (1) open fracture with vascular damage (Gustilo-Anderson IIIC type); (2) Multiple fractures; (3) Patients who are known to be allergic to normal saline or EDTA or to root canal irrigation during dental surgery; (4) Previous local wound infection or history of osteomyelitis in the injured limb; (5) Presence of digestive tract infection or lung infection (6) Injured for more than 24 hours (7) Patients who have used immunosuppressive drugs or taken glucocorticoids for a long time within 6 months; (8) Patients in the chemotherapy phase of tumors; (9) Patients with immunodeficiency diseases (such as HIV); (10) Patients with hand fractures (metacarpophalangeal fractures); (11) Patients with phalangeal fractures (12) Patients who have participated in other clinical studies; (13) The patient is a prisoner or a high-risk patient who is incarcerated during the follow-up period; (14) Patients with mental illness, Alzheimer's disease or inability to communicate; (15) Pregnant patients; (16) Patients who are unable to participate in the full course of the study within 12 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Secondary operation occurs due to recurrence of infection, poor wound healing, or poor fracture healing within 12 months of initial surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| SF-12 scale scoring;Details of non-surgical treatment forrecurrence of infection, poor wound healing, or poor fracture healing within 12 months of initial surgery;SPOC scale scoring; | — |
Countries
China
Contacts
Public ContactXianyou Zheng
Shanghai Sixth People's Hospital
Outcome results
None listed