Postoperative sleep disturbance
Conditions
Interventions
remazolam group:Propofol (2-4 mg/kg) was used for anesthesia induction and propofol (4-12 mg/kg/h) was used for anesthesia maintenance.
propofol group:Remazolam 0.2 to 0.3 mg/kg was used for anesthesia induction and remazolam 1.0 to 3.0 mg/kg/h for anesthesia maintenance
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age= 60 years old; 2. Patients who intend to undergo surgery for lung segment, lobe or total lung resection under elective general anesthesia. 3. The estimated end time of the operation is before 20:00
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Severe cardiac insufficiency (preoperative LVEF < 30% or NYHA grade IV); 3. Severe liver function abnormalities (Child-Pugh grade C); 4. Severe renal dysfunction (receiving dialysis before surgery); 5. ASA grade IV or above; 6. Allergy to study drugs; 7. Inability to communicate and cooperate due to severe dementia or language impairment before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total sleep duration on the night of surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep efficiency, number of wakefulness and fragmentation index on the night of surgery;Total sleep duration, sleep efficiency, number of wakes and fragmentation index on the first and second nights after surgery;Subjective sleep quality score from the night of surgery to the night of the second day after surgery;Prefrontal-temporal brain network connection function before surgery, after loss of consciousness, and when consciousness is restored;Quality of sleep on day 30 postoperatively; | — |
Countries
China
Contacts
Public ContactDongliang Mu
Peking University First Hospital
Outcome results
None listed