Labor analgesia
Conditions
Interventions
0.0% chloroprocaine group (RP):0.0% chloroprocaine+different concentrations of ropivacaine+sufentanil 0.4 µ g/ml, infusion for 10ml as a bolus first.
0.2% chloroprocaine group (LP0.2):0.2% chloroprocaine+different concentrations of ropivacaine+sufentanil 0.4 µ g/ml, infusion for 10ml as a bolus first.
0.3% chloroprocaine group:0.3% chloroprocaine+different concentrations of ropivacaine+sufentanil 0.4 µ g/ml, infusion for 10ml infusion for 10ml as a bolus first.
Sponsors
Hefei Maternal and Child Health Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Full term and single primiparous women with ASA grades I-II; 2. Aged 20-35 years; 3. BMI 21-30 kg/m^2; 4. Gestational age 37-41 weeks, all enter the latent period of the first stage of labor (cervical dilation <6 cm), and a visual analogue scale (VAS) pain score exceeding 5 during contractions; 5. All primiparous women voluntarily and knowingly agreed to receive PCEA delivery analgesia.
Exclusion criteria
Exclusion criteria: 1. Contraindications for intraspinal puncture, such as coagulation dysfunction, infection or injury at the puncture site, spinal lesions or severe spinal deformities, neurological diseases or neuropathies; 2. Allergy to local anaesthetics; 3. Multipara, abnormal fetal position, IVF; 4. Severe heart, lung, liver, kidney and other important system diseases; 5. Pathological obstetrics, such as pregnancy complications (high-risk pregnancies such as severe preeclampsia, placental abruption, and placenta previa); 6. Those who cannot undergo vaginal delivery after obstetric evaluation; 7. The inability of pregnant women to cooperate due to combined mental illness or other conditions; 8. Used opioids, tranquilizers, or other analgesics 6 hours or recently before anesthesia; 9. History of allergies to esters, amides, and local anesthetics such as opioids and procaine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The concentration of ropivacaine (EC50 and EC90); | — |
Secondary
| Measure | Time frame |
|---|---|
| The onset of labor analgesia;The rate of breakthrough pain;The rate of perineal distension and pain;Maximum VAS score after analgesia;Average VAS score during analgesia;Times of rescue analgesia;Maternal satisfaction scores;Intensity of uterine contractions (IUCs) ;The thoracic highest sensory level (ice pack method);Motor blockade;Outcomes of delivery, mother and baby ;Analgesic effect; | — |
Countries
China
Contacts
Public ContactHaijuan Zhu
Hospital Maternal and Child Medical Center of Anhui Medical University (Hefei Maternal and Child Health Hospital)
Outcome results
None listed