Syphilis, gonorrhea and chlamydia
Conditions
Interventions
control group:1. Doxy-PEP education: co-created educational information on doxy-PEP use and safety
2. Self-pay doxy-PEP: opportunity to purchase doxy-PEP pack at clinic. Each pack will include one bot
PIF group:1. Doxy-PEP education: co-created educational information on doxy-PEP use and safety.
2. Free doxy-PEP donated through pay-it-forward: opportunity to receive a free doxy-PEP packet. Each pac
SNPIF group:1. Doxy-PEP education: co-created educational information on doxy-PEP use and safety.
2. Free doxy-PEP donated through pay-it-forward: opportunity to receive a free doxy-PEP packet. Each p
Sponsors
Dermatology Hospital of Southern Medical University
Eligibility
Sex/Gender
Male
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 16 years; 2. Identify as a cisgender man or transgender woman; 3. Report previously having anal or oral sex with a man; 4. Report having at least one of the following risk factors for STI acquisition in the past 12 months: >= 1 bacterial STI diagnosis, anal sex with >= 2 male partners, or condomless anal or oral sex with >= 1 male partner; 5. Provide informed consent and personal contact information, including a cell phone number or WeChat ID.
Exclusion criteria
Exclusion criteria: 1. Report previous allergy to tetracycline antibiotics; 2. Taking medications which may impact doxycycline metabolism or that are contraindicated with doxycycline, as per the prescribing information (e.g., systemic retinoids, barbiturates, carbamazepine, and phenytoin); 3. Taking warfarin, as intermittent doxycycline use can lead to an unpredictable impact on INR; 4. Anticipate use of doxycycline during the coming 12 months for non-STI prevention (e.g., acne treatment).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| uptake of doxy-PEP: the proportion of participants who report using doxy-PEP within 72-hours of condomless anal or oral sex on =1 occasion during the 6-month follow-up period after enrollment.; | — |
Secondary
| Measure | Time frame |
|---|---|
| proportion of participants who obtain a doxy-PEP packet at baseline;frequency of doxy-PEP use during the follow-up period, including the proportion of participants who report using doxy-PEP within 72 hours of condomless anal or oral sex on >= 50% and on 100% of such occasions, respectively;combined incidence of syphilis, gonorrhea, and chlamydia;proportion of index participants who disseminate doxy-PEP packets or peer referral cards to >= 1 peer during follow-up (control and pay-it-forward with adjunctive social network distribution arms only);tetracycline resistance in N. gonorrhoeae and C. trachomatis isolated at baseline as compared with organisms isolated in the follow-up period;proportion of participants who donated any amount (pay-it-forward and pay-it-forward with adjunctive social network distribution arms only); 10) the total donated amount (pay-it-forward and pay-it-forward with adjunctive social network distribution arms only);total donated amount (PIF and SNPIF arms only);self-reported STI diagnoses, symptoms, and treatment-seeking behaviors that occurred outside of study visits, including care obtained from non-study clinics or pharmacies;acceptability, appropriateness, and fidelity of doxy-PEP disseminated through social network distribution (pay-it-forward with adjunctive social network distribution arm only);time from enrollment to first doxy-PEP use; | — |
Countries
China
Contacts
Public ContactWang Cheng
Dermatology Hospital of Southern Medical University
Outcome results
None listed