Study on the respiratory and intestinal microbiota and their metabolites in children with lobar/segmental pneumonia under different pathogen infections
Conditions
Interventions
infection groups:None
non infectious groups:None
Sponsors
The First Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
No minimum to 14 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for infection group: (1) Age: 29 days = Age = 14 years old; (2) The time from onset to admission is = 10 days; (3) Conforming to the diagnostic criteria for lobar pneumonia: having symptoms of respiratory tract infection such as fever and/or cough, chest imaging examination indicating uniform consolidation of one or more segments, one or more lobes of the lung, excluding pulmonary tuberculosis and space occupying lesions; (4) Comply with the indications for bronchoscopic alveolar lavage surgery and implement it in accordance with the expert consensus of the 2018 edition of the Chinese Pediatric Flexible Bronchoscopy Guidelines. Inclusion criteria for non infectious groups: (1) Age: 29 days = Age = 14 years old; (2) The time from onset to admission is = 10 days; (3) Conforming to the diagnostic criteria for bronchial foreign body: ? All children have a clear history of foreign body coughing; ? All patients underwent chest X-ray or CT scans before surgery; (4) Comply with the indications for bronchoscopic alveolar lavage surgery and implement it in accordance with the expert consensus of the 2018 edition of the Chinese Pediatric Flexible Bronchoscopy Guidelines.
Exclusion criteria
Exclusion criteria: Exclusion criteria for infection groups: (1) Contraindications to bronchoscopy lavage include heart failure, severe arrhythmia, severe pulmonary insufficiency, and acute respiratory failure. (2) History of respiratory diseases such as hospital acquired pneumonia, pulmonary tuberculosis, bronchial asthma, pulmonary thromboembolism, atelectasis, and lung tumors. (3) Those who have combined diseases of the blood system, rheumatic connective tissue, and other systems that affect the diagnosis and treatment process; (4) Those who are intolerant of bronchoscopy diagnosis and treatment and interrupt treatment; (5) Individuals who are allergic to the use of drugs such as anesthetics during bronchoscopy; During the follow-up period, there was a new outbreak of pneumonia; (6) During the hospitalization of this course of illness, there were cases of hospital infection; Those who transfer or discontinue treatment without authorization midway, and whose clinical data is incomplete; (7) Participate in this study while also participating in other experimental researchers (8) Patients who refuse to provide samples or cooperate after initial consent. (9) Patients with mixed infections. Exclusion criteria for non infectious groups: (1) Contraindications to bronchoscopy lavage include heart failure, severe arrhythmia, severe pulmonary insufficiency, and acute respiratory failure. (2) History of respiratory diseases such as hospital acquired pneumonia, pulmonary tuberculosis, bronchial asthma, pulmonary thromboembolism, atelectasis, and lung tumors. (3) Those who have combined diseases of the blood system, rheumatic connective tissue, and other systems that affect the diagnosis and treatment process; (4) Those who are intolerant of bronchoscopy diagnosis and treatment and interrupt treatment; (5) Individuals who are allergic to the use of drugs such as anesthetics during bronchoscopy; (6) Those who transfer or discontinue treatment without authorization midway, and whose clinical data is incomplete; (7) Participate in this study while also participating in other experimental researchers (8) Patients who refuse to provide samples or cooperate after initial consent. (9) Patients with symptoms of respiratory and digestive tract infections such as cough, expectoration, nasal congestion, runny nose, sore throat, vomiting, diarrhea, abdominal pain, etc. (10) Patients with residual foreign bodies still present under imaging and bronchoscopy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microbial characteristics table;cytokine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Shannon Diversity Index;metabolite; | — |
Countries
China
Contacts
Public ContactMan Gao
The First Hospital of Jilin University
Outcome results
None listed