stroke
Conditions
Interventions
Test group:transcranial electrical stimulation
Control group:sham stimulation
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. First stroke; 2. The lesions located in the cerebral hemisphere cortex and subcortical; 3. The course of disease was between 2 weeks and 3 months; 4. Hamilton Depression Scale (HAMD) score > 8 points; 5. Pittsburgh Sleep Quality Index (PSQI) >= 8 or subjective sleep difficulty; 6. Mild to moderate cognitive impairment (10 <= MMSE < 26 points); 7. Aged 35-75 years; 8. Stable vital signs without progressive neurological symptoms; 9. If cognitive-improving or antidepressant drugs were used, no dose adjustment was made within 1 week; 10. Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Previous history of brain tumor, traumatic brain injury, epilepsy or mental disorder; 2. After craniotomy/skull defect; 3. Metal or electronic device implants (such as cardiac pacemakers, cochlear implants, deep brain stimulators, aneurysm clips, internal fixation devices after ventriculoperitoneal shunt, etc.); 4. Impaired skin integrity at the electrode placement site, or allergy to electrode gel or adhesive; 5. Severe aphasia, visual and hearing impairment, able to complete the study protocol; 6. Unstable heart disease, hypertension, and other serious medical conditions that may affect the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;function connectivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Digit Span Test;Fugl-Meyer Assessment;Hamilton Depression Scale;Pittsburgh Sleep Quality Index;Modified Barthel Index; accuracy of GONOGO;Amplitude and latency of event-related potentials; | — |
Countries
China
Contacts
Public ContactXiquan Hu
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed