OCD, MDD, Addction
Conditions
Interventions
theta-burst TUS:The NeuroFUS Pro transcranial ultrasound stimulator is used, consisting of the Transducer Power Output TPO-203 and a four-element transducer CTX-500. The ultrasound stimulation paramet
40-s offline protocol:The NeuroFUS Pro transcranial ultrasound stimulator (using Transducer Power Output TPO-203 and a four-element transducer CTX-500) is employed. The ultrasound stimulation paramete
Sponsors
Zhongshan Hospital
Eligibility
Sex/Gender
All
Age
22 Years to 50 Years
Inclusion criteria
Inclusion criteria: Healthy Controls: 1) Age 18-60 years, both males and females, right-handed. 2) No clear diagnosis of physical or mental illness. 3) Signed informed consent form. 4) Normal vision or corrected visual acuity. 5) Participants capable of completing the specified tests according to the protocol. Psychiatric Patients: 1) Age 18-60 years, both males and females, right-handed. 2) Primary diagnosis of one of the following mental disorders (meeting DSM-V diagnostic criteria): obsessive-compulsive disorder, depression, substance addiction (including but not limited to nicotine, alcohol, heroin, methamphetamine, or methadone). 3) Disease severity: For obsessive-compulsive disorder patients, Yale-Brown Obsessive-Compulsive Scale score > 19; for depression patients, Hamilton Depression Rating Scale 17-item total score = 17; for substance addiction patients, at least 3 previous failed attempts at abstinence. 4) Stable medication treatment plan in the past month. 5) Signed informed consent form. 6) Normal vision or corrected visual acuity. 7) Participants capable of completing the specified tests according to the protocol.
Exclusion criteria
Exclusion criteria: 1. Applicable to all participants: a) Abnormal cognitive status (assessed using MoCA with a score 19. 3. Psychiatric Patients: a) Previous or concurrent neurological disorders: cerebrovascular disease, central nervous system infections, Creutzfeldt-Jakob disease, Huntington's disease, Parkinson's disease, frontotemporal dementia, traumatic brain injury-related dementia, other physical and chemical factors (drugs, alcohol, CO, etc.), significant physical diseases (hepatic encephalopathy, pulmonary encephalopathy, etc.), intracranial space-occupying lesions (subdural hematoma, brain tumors), endocrine system disorders (thyroid disease, parathyroid disease), and any dementia caused by vitamin or other reasons. b) Comorbidities with other psychiatric disorders (e.g., comorbid depression in patients with obsessive-compulsive disorder).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Behavioral outcome;Clinical outcome;Physiological outcome; | — |
Countries
China
Contacts
Public ContactWenjuan Liu
Zhongshan Hospital
Outcome results
None listed