amnesia mild cognitive impairment
Conditions
Interventions
Golden needle "Tiao Shen" accupuncture group:Golden needle "Tiao Shen" accupuncture
Filiform needle "Tiao Shen" accupuncture group:Filiform needle "Tiao Shen" accupuncture
Sham acupuncture group:Sham acupuncture
Healthy control group:No intervention
Sponsors
Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meets the aMCI diagnostic criteria; (2) The first onset, with a history of memory impairment of = 3 months, and no history of other neurological or psychiatric diseases; (3) Clinical Dementia Rating Scale (CDR) score 0.5 points; (4) Age range from 50 to 75 years old, regardless of gender; (5) Education experience = 1 year; (6) Volunteer participation, with informed consent signed by the individual.
Exclusion criteria
Exclusion criteria: (1) Previous intracranial hemorrhage or ischemic disease accompanied by focal neurological signs, with imaging evidence supporting cerebral hemorrhage,Tubular diseases (Fazekas score = 2 points); (2) Suffering from other nervous system disease that may cause brain function damage (such as epilepsy, depression, intracranial tumors,Kinsen's disease, metabolic diseases, encephalitis, multiple sclerosis, traumatic brain injury, normal intracranial pressure hydrocephalus, etc.); (3) Cognitive impairment caused by other systemic diseases: such as liver dysfunction, renal dysfunction, thyroid dysfunction, severe anemia, folic acid and vitamin B12 deficiency, CO poisoning, special infections (such as syphilis, AIDS), alcohol and drug abuse; (4) Existence of mental and neurological developmental delays; (5) There are contraindications for magnetic resonance imaging examination; (6) Suffering from diseases that cannot cooperate in completing cognitive tests; (7) Have taken anti dementia treatment medication within one month, such as donepezil, galantamine, rivastigmine, memantine, etc; (8) Participants refused to sign a written informed consent form to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment,MOCA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional Activities Questionnaire,FAQ;Hamilton Anxiety Scale;Hamilton Depression Scale;fMRI; | — |
Countries
China
Contacts
Public ContactWang Xin
Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University
Outcome results
None listed