Metabolic syndrome, weight loss surgery
Conditions
Interventions
Dexmetomidine combined with Esketamine group:Before surgery, 1 ug/kg of dexmedetomidine was administered for 10 minutes to complete the pump injection, and 0.5 mg/kg of ketamine was administered durin
Intraoperative pump infusion of 0.4ug/kg/h dexmedetomidine and 0.1mg/kg/h eszketamine until 40 minutes before the end of the surgery
Dexmetomidine group:Preoperative administration of 1 µ g/kg of dexmedetomidine for 10 minutes to complete the pump infusion, and intraoperative infusion of 0.4 µ g/kg/h of dexmedetomidine until 40 min
Esketamine group:During induction, 0.5 mg/kg of ketamine was administered
Intraoperative pump infusion of 0.1mg/kg/h of Esketamine until 40 minutes before the end of the surgery
control group:Provide equal volume of physiological saline at the same time point
Sponsors
Xuzhou Medical University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? Patients with a BMI = 30kg/m2 who undergo elective laparoscopic gastric volume reduction surgery; ? Age: 18-65 years old; ? ASA classification II-III; ? Sign an informed consent form.
Exclusion criteria
Exclusion criteria: ? Patients who cannot tolerate general anesthesia, such as allergies to general anesthesia drugs; ? Allergies and contraindications to dexmedetomidine (pregnant and lactating women, third degree atrioventricular block); ? Allergies and contraindications to ketamine drugs; (Patients with high blood pressure or severe elevated intracranial pressure at serious risk; poorly controlled or untreated hypertension patients; glaucoma; untreated or insufficiently treated hyperthyroidism patients); ? Concomitant severe cardiovascular diseases (such as myocardial infarction, heart failure, malignant arrhythmia, etc.), kidney diseases (glomerular filtration rate<60ml/(min · 1.73m2) -1), liver diseases (serum total bilirubin = 2mg/dl); ? Have taken antidepressants or received other antidepressant treatments in the past 4 weeks; ? Patients with moderate or above anemia (hemoglobin<90g/L); ? Chronic pain, long-term use of opioid analgesics, corticosteroids, and/or pregnancy; ? Having a history of drug abuse, mental illness, communication disorders, etc; ? Patients who are unable to complete the scale involved in this study; ? Patients who have participated in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recovery quality within 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS scores;Intraoperative hemodynamic changes;Perioperative use of propofol and remifentanil;Consumption of remedial analgesics within 24 hours;Extubation time;First time out of bed after surgery;First postoperative exhaust time;Awakening restlessness score;Adverse reaction rate; | — |
Countries
China
Contacts
Public ContactWang Guanglei
Xuzhou Medical University Affiliated Hospital
Outcome results
None listed