Chill
Conditions
Interventions
Chilling group:The first participant received oxycodone 80 µg/kg intravenously after the infant's section. When the previous subject had chills, the concentration of the next subject increased by 5 µg
Non-chill group:When chills were not observed in the previous patient, the next patient was randomized to receive the same dose of oxycodone (probability 0.89) or oxycodone at a concentration 5 µg/kg
Sponsors
Hangzhou First People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. ASAI-II level; 2. Age 18-40 years old; 3. 150cm= height = 170cm, weight = 100kg; 4. Gestational age= 37 weeks; 5. Patients undergo routine pregnancy examination; 6. There are no abnormalities in blood routine and coagulation function; 7. Heart, liver, lung, kidney and other functions are correct; 8. Elective caesarean section under lumbar hard combined anesthesia; 9. The mother signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergic to the drugs used in the Institute; 2. Spinal deformity; 3. Twin and/or multiple pregnancies; 4. Coagulation dysfunction; 5. Infection at the puncture site; 6. Maternal refusal to participate in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MEC90; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of chills;Chill grading;When and how long chills occur;Ramsay score ;Heart rate and blood pressure change every 5 minutes after administration;Incidence of adverse events (nausea, vomiting, respiratory depression).;Postoperative 2h and 6h VAS pain scores; | — |
Countries
China
Contacts
Public ContactJianliang Sun
Hangzhou First People's Hospital
Outcome results
None listed