thoracoscopic lung surgery
Conditions
Interventions
liposomal bupivacaine group (LB group):preoperative using liposomal bupivacaine for ultrasound-guided erector spinae plane block
bupivacaine HCl group (BUPI group):preoperative using bupivacaine HCl for ultrasound-guided erector spinae plane block
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. ASA class I-III; 2. Aged 18-75 years; 3. Subjects scheduled for elective video-assisted thoracoscopic single or multi-port lung surgery under general anesthesia with bronchial intubation.
Exclusion criteria
Exclusion criteria: 1. Trauma and emergency subjects; 2. New York Heart Function Scale (NYHA) levels 3-4; 3. Heart conduction block (sinus block or atrioventricular block); 4. Unstable coronary artery disease; 5. Gastric ulcer or gastric bleeding; 6. Body mass index (BMI) 37 kg/m2; 7. Diabetes being treated with insulin; 8. Renal dysfunction (serum creatinine values exceed normal thresholds); 9. Liver dysfunction (Alanine aminotransferase or Aspartate aminotransferase is more than twice the normal value); 10. Subjects with coagulation dysfunction (prothrombin time or activated partial thromboplastin time is higher than the normal threshold) or patients who are taking oral anticoagulants for other medical reasons and have not stopped before surgery, such as warfarin or new anticoagulants rivaroxaban or dabigatran; 11. Alcohol abuse or heavy dependence on narcotic drugs in the last two months; 12. Uncontrolled anxiety, schizophrenia or other mental illness; 13. Subjects who are pregnant or prepare for pregnancy; 14. Subjects with a history of allergy to local anesthetic drugs or any of the experimental medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve of pain score at rest during 0-72 hours postoperatively (AUC NRS-R 0-72); | — |
Secondary
| Measure | Time frame |
|---|---|
| Total amount of opioid remedial analgesics converted to morphine during 0-72 hours postoperative;Time to first press on the PCIA device as remedial analgesia;Area under the curve of pain scores on activity during 0-72 hours (AUC NRS-A0-72) postoperatively;NRS scores at rest and on activity at different time points during the 72-hour postoperative period;Quality of Recovery 15 (QoR-15) scores at 72 hours after surgery;NRS score on activity on postoperative day 14;NRS scores on activity at postsurgical 3 months; | — |
Countries
China
Contacts
Public ContactFuhai Ji
The First Affiliated Hospital of Soochow University
Outcome results
None listed