scoliosis
Conditions
Interventions
Con group:The anesthesia induction scheme is Midazolam 2~4mg+sufentanil 0.3~0.4 µ g/kg+Etomidate 0.2 mg/kg+cisatracurium 0.15~0.20 mg/kg. Propofol 4-8mg/(kg · h)+remifentanil 0.1-0.3 µ g/(kg · min)+ci
Dex group:On the basis of the Con group, the Dex group was combined with dexmedetomidine hydrochloride, before anesthesia induction 0.5 µg/kg of dexmedetomidine hydrochloride was injected within 10 mi
Rem group:Rem group was combined with remazolam toluenesulfonate on the basis of the Con group. The drug was administered at a rate of 0.3 mg/kg during anesthesia induction and 1.0~2.0 mg/(kg · h) dur
Sponsors
Shifang People's Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: ? Patients with lateral curvature of the spine greater than 10 ° according to X-ray examination and scheduled for scoliosis correction surgery; ? Normal cognitive and communication abilities, able to cooperate in completing relevant scale assessments; ? The American Association of Anesthesiologists (ASA) is classified as Level I-III; ? Body mass index (BMI) 18-28kg/m2.
Exclusion criteria
Exclusion criteria: ? Severe hypertension or diabetes; ? Coronary heart disease; ? Central nervous system disease; ? Difficult airway; ? Allergies to the study Drug allergy; ? Intermittent or long-term use of benzodiazepines or opioids within 2 months prior to admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative arousal quality;VAS scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| interleukin-10;interleukin-6;Tumor Necrosis Factor- a;PGE2;HMGB1;adrenaline;norepinephrine;cortisol; | — |
Countries
China
Contacts
Public ContactLin Zeng
Shifang People's Hospital
Outcome results
None listed