Valvular heart disease
Conditions
Interventions
melatonin group:Before surgery, melatonin was given 10mg/ d for 5 days
placebo group:Placebo was given continuously for 5 days before surgery
Sponsors
The First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: The patients who received heart valve replacement in the First Affiliated Hospital of Kunming Medical University were selected. ? Patients with mitral or aortic valve related diseases; ? Clear consciousness, no mental disorders, and able to cooperate in completing preoperative cognitive assessment; ? Not taking sleeping aids; ? Age 18-65 years old; ? BMI (Body mass index) < 30kg/m2.
Exclusion criteria
Exclusion criteria: ? Patients with history of myocardial infarction and cerebral infarction and mental disorders; ? Patients with severe hepatic and renal insufficiency; ?Those who refused to participate in the experiment; ? preoperative ejection fraction <40%; ? those who cannot communicate verbally
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Malondialdehyde MDA;Blood glucose;Cognitive function ;Superoxide Dismutase (SOD);Cardiac troponin I (cTnI);creatine kinase isoenzyme(CK-MB); | — |
Secondary
| Measure | Time frame |
|---|---|
| Astroglial derived protein (S100B); | — |
Countries
China
Contacts
Public ContactWendong Chen
The First Affiliated Hospital of Kunming Medical University
Outcome results
None listed