chronic cough
Conditions
Interventions
Patients with chronic cough:none
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-80 years old; (2) Chronic cough lasting for = 8 weeks or 3 weeks with a history of similar illness, and no significant abnormalities in chest CT; (3) Meet any of the following criteria: ? FeNO = 25ppb; ? The total IgE exceeds the normal range; ? Blood EOS = 0.1 * 10 ^ 9/L; (4) Before being included in the queue, it is necessary to sign an informed consent form and be able to participate in the research protocol and conduct follow-up according to the protocol.
Exclusion criteria
Exclusion criteria: (1) Within four weeks before enrollment, systemic corticosteroids, ICS or ICS combined with LABA or ICS combined with LABA+LAMA were used; Or acute respiratory infections may occur; (2) Suffering from clearly diagnosed chronic respiratory diseases, such as COPD, cystic fibrosis, bronchiectasis, interstitial lung disease, tuberculosis, lung cancer, etc; (3) Patients have known important risk factors for cough, including but not limited to: taking ACEI/ARB drugs; (4) Patients with serious systemic diseases, including heart failure, renal failure, liver failure, but basic diseases such as hypertension, coronary heart disease, diabetes do not need to be excluded (basic diseases are stable, only need drug maintenance), and maintain the use of the original drug regimen; (5) Women of childbearing age who are currently pregnant or breastfeeding; (6) Individuals who have received immunosuppressive therapy or participated in clinical research three months prior to enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale,VAS;Reflux symptom index,RSI;Hull airway reflux questionnaire,HARQ;Asthma Control Questionnaire 5 ,ACQ-5;The Leicester Cough Questionnaire,LCQ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary function; | — |
Countries
China
Contacts
Public ContactLiu Yi
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Outcome results
None listed