severe periodontitis
Conditions
Interventions
control group:minimally invasive tooth extraction
test group 1:Minimally invasive tooth extraction, implanting bio-oss into the extraction socket, and applying Bio Gide absorbable membrane covering bone graft materials and defect areas. Cover the sof
test group 2:Minimally invasive tooth extraction with Bio-Oss Collagen implanted in the extraction socket, Bio-Gide absorbable membrane covering bone graft materials and defect areas. Cover the soft t
test group 3:Minimally invasive tooth extraction with REBONE bone meal implanted in the extraction socket, Bio-Gide absorbable membrane covering bone graft materials and defect areas. Cover the soft t
test group 4:Minimally invasive tooth extraction with OSTEO GRART bone meal implanted in the extraction socket, Bio-Gide absorbable membrane covering bone graft materials and defect areas. Cover the s
Sponsors
Peking University Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with hypertension and diabetes who are generally healthy or well controlled; 2. Can maintain good oral hygiene and good compliance; 3. There are teeth in the mouth that need to be extracted due to severe periodontal disease: PD > 6mm, AL >= 5mm, imaging examination shows alveolar bone resorption exceeding 1/2 or more of the root length, molar with furcation involvement, and tooth looseness > II°; 4. There is bone defect in the affected alveolar fossa, with at least two bone walls with a height of >= 3mm (buccal,lingual, mesial and distal bone walls); 5. At least one adjacent tooth exists.
Exclusion criteria
Exclusion criteria: 1. Patients aged = 10 cigarettes per day; 3. Pregnant or lactating women; 4. History of head and neck radiation therapy; 5. Long term use of non-steroidal anti-inflammatory drugs, corticosteroids, tetracyclines, bisphosphonates, or other drugs that affect bone regeneration; 6. The dentition is significantly crowded, ectopic, and twisted; 7. There is acute infection of the affected tooth; 8. Gingival hyperplasia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes in width of buccal keratinized tissue and soft tissue thickness;changes in three-dimensional morphology of soft and hard tissue contours;changes in height and width of alveolar bone;changes in soft tissue morphology;histology of bone blocks;periodontal clinical indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative reactions;bone grafting during implantation surgery;Health Economics;surgical time; | — |
Countries
China
Contacts
Public ContactHu Wenjie
Peking University School and Hospital of Stomatology
Outcome results
None listed