Coronary Arteriosclerotic Heart Disease
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged 40-70 years old, with cardiac function of II to III (NYHA standard), scheduled for elective off-pump coronary artery bypass graft surgery under general anesthesia; 2. Signing of written informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergies to local anesthetics or contraindications to ropivacaine; 2. Coagulopathy; 3. Infection at the injection site; 4. Previous neurologic or psychiatric disorders; 5. Uncontrolled diabetes, chronic obstructive pulmonary disease, abnormal liver function, and renal insufficiency (glomerular filtration rate < 15 mL/min/1.73m2). 6. Long-term opioid use, pregnancy, and inability to communicate with patients; 7. Use of other investigational drugs or participation in other clinical trials in the three months prior to selection for the study; 8. Patients who have previously undergone eye surgery or have abnormal pupils; 9. Patients who are unable to participate in the study for any reason or who are deemed unsuitable for participation in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (visual analogue scale, VAS) score in resting state; (visual analogue scale, VAS) score during coughing; | — |
Secondary
| Measure | Time frame |
|---|---|
| (visual analogue scale, VAS) score in resting state;(visual analogue scale, VAS) score during coughing;Total amount of sufentanil ;The first press time of patient controlled intravenous analgesia (PCIA);Number of patient controlled intravenous analgesia (PCIA) compressions in 48h;postoperative recovery time ;Time of tracheal tube removal;Ventilator support time;(intensive care unit, ICU) retention time;Removal time of chest wall drainage tube;Total hospitalization time;Surgery to discharge time;Hospital costs;Incidence of postoperative adverse actions;pupil diameter; | — |
Countries
China
Contacts
Xinqiao Hospital of Army Medical University