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The effect of different anesthesia maintenance programs on postoperative respiratory adverse events in childrenundergoing tonsillectomy and adenoidectomy: a multicentre randomized clinical trial

The effect of different anesthesia maintenance programs on postoperative respiratory adverse events in childrenundergoing tonsillectomy and adenoidectomy: a multicentre randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300074803
Enrollment
Unknown
Registered
2023-08-16
Start date
2023-08-15
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertrophy of tonsils and adenoids

Interventions

IV anesthesia maintenance group:Propofol 8-12(mg·kg-1·h-1 continuous intravenous infusion
inhalation maintenance group:Sevoflurane 2-3% was continuously inhaled by anesthesia machine
IV inhalation compound maintenance group:Sevoflurane 1% was continuously inhaled by an anesthesia machine AND propofol 4-6 (mg·kg-1·h-1) was continuously infused intravenously

Sponsors

Zhongda Hospital Affiliated to Southeast University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 12 Years

Inclusion criteria

Inclusion criteria: (1) ASA is grade ?~?; (2) Age = 12 years old; (3) Elective tonsillectomy and/or adenoidectomy under general anesthesia are planned.

Exclusion criteria

Exclusion criteria: (1) Congenital diseases or abnormal liver and kidney function; (2) Chronic lung diseases (cystic fibrosis, bronchial dysplasia, pulmonary hypertension, etc.); (3) Severe upper respiratory tract infection before operation; (4) Neuromuscular diseases, cerebral palsy, epilepsy; (5) Has been intubated, or has undergone tracheotomy; (6) Those who plan to enter the ICU after surgery; (7) Difficult airway; (8) The chief anesthesiologist recommends a specific anesthesia maintenance plan, and random allocation is not recommended; (9) Family members or guardians refuse to participate.

Design outcomes

Primary

MeasureTime frame
Perioperative Respiratory Adverse Events(including any of the following: laryngospasm, bronchospasm, hypoxia, prolonged cough, airway obstruction, wheezing);

Secondary

MeasureTime frame
Frequency of the individual respiratory adverse events.;Occurrence of respiratory adverse events during the different phases of anesthesia;Occurrence of respiratory adverse events during the different phases of anesthesia;Post-extubation pain score;PAED score;

Countries

China

Contacts

Public ContactJie Sun

Zhongda Hospital Affiliated to Southeast University

dgsunjie@hotmail.com+86 158 9597 1012

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026