post-stroke spasticity
Conditions
Interventions
Experimental group:Sangdantongluo granule
Standardized treatment of western medicine based on the Guidelines
Control group:Sangdantongluo granule placebo
Standardized treatment of western medicine based on the Guidelines
Sponsors
Hunan Provincial Hospital of Integrated Traditional Chinese And Western Medicine(Hunan Academy of Chinese Medicine Affiliated Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: ?Western medicine diagnosis conforms to the diagnostic criteria of cerebral infarction; ?TCM syndrome meets the criteria of yin deficiency and blood stasis syndrome; ?First-episode,duration ranges from 15 days to 90 days; ?Aged >= 18 and = 1, and <= grade 3;No symptoms of neurological deficits such as aphasia, dysarthria, dysphagia, facial paralysis, cognitive impairment, etc; ?Conscious patients (GCS score = 15),able to cooperate with consultation, physical examination, instructions, and treatment; ?Determined as right-handed by the Chinese Handedness Scale; ?Patients who had not participated in other clinical trials in the last 3 months; ?Patients or their family members agreed and signed informed consent.
Exclusion criteria
Exclusion criteria: ?Previous motor dysfunction, such as rheumatoid arthritis, limb surgery, joint deformities, multiple sclerosis, spinal cord injury, or neuromuscular lesions that affect limb activity; ?Patients with a history of stroke and limb spasticity; ? Inability to understand and/or follow up research procedures and/or follow-up due to mental illness, cognitive or emotional disorders; ?Patients with a history of long-term alcoholism or taking central nervous system active drugs; ?Patients with severe hepatorenal insufficiency (defined as ALT > 2 times the normal upper limit or AST > 2 times the normal upper limit). Severe renal insufficiency is defined as Cr > 1.5 times normal upper limit); ?Complicated with other life-threatening diseases such as severe heart, liver, kidney and endocrine diseases with an expected survival time of less than 3 months; ?Received anti spasmodic treatment within 2 weeks prior to enrollment, such as oral anti spasmodic drugs; ?Allergic to Sangdantongluo granule; ?Pregnant or lactating women; ?Ischemic stroke caused by other non-arteriosclerosis, such as intracranial tumor, heart disease, blood disease, brain trauma and so on; ?MRI or TMS Contraindication, such as metal implants and Claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Ashworth Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Upper Limb Fugl Meyer Scale;National Institute of Health Stroke;Modified Rankin Scale;Cortical excitability test;multimodal functional magnetic resonance imaging(fMRI); | — |
Countries
China
Contacts
Public ContactLe Xie
Hunan Provincial Hospital of Integrated Traditional Chinese And Western Medicine(Hunan Academy of Chinese Medicine Affiliated Hospital)
Outcome results
None listed