Insomnia disorder
Conditions
Interventions
patients with insomnia:No intervention in this study.
Healthy subjects:No intervention in this study.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (1) Patients with insomnia: the symptoms of the consultation met the diagnostic criteria of ICSD-3. (2) Healthy subjects: healthy, no complaints of sleep disorders (e.g., insomnia, narcolepsy, restless legs syndrome, etc.), no OSA (i.e., AHI < 5 /hour), periodic limb movements (PLMI < 15 /hour) or other sleep disorders as indicated by overnight PSG monitoring.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with insomnia: 1) medical factors causing nighttime sleep disruption (e.g., itching and pain); 2) current mental illness status (e.g., schizophrenia, bipolar disorder, major depression disorder); 3) current or past use of antidepressants, anxiolytics, sedative-hypnotics, or other psychotropic medications in the past 3 months; 4) sleep-related limb movement disorders (e.g. periodic limb movement index based on PSG, PLMI = 15 beats/hour); 5) other sleep disorder co-morbidities (e.g., narcolepsy, restless legs syndrome, etc.) found in the collection of sleep disorders; 6) other major cardiopulmonary disorders (e.g., coronary artery disease, cardiomyopathy, chronic obstructive pulmonary disease), cerebrovascular disorders, endocrine disorders (e.g., diabetes mellitus, Cushing's syndrome, etc.), and hepatic and renal disorders found in the collection of medical history. syndrome, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| percentage of NREM sleep;percentage of REM sleep;Arousal Index;PLMSI;DNA methylation detection;sleep latency;REM latency; | — |
Secondary
| Measure | Time frame |
|---|---|
| AHI;sleep electroencephalographic activity; | — |
Countries
China
Contacts
Public ContactYe Zhang
West China Hospital, Sichuan University
Outcome results
None listed