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The protective effect and mechanism of bilateral thoracic paravertebral nerve block on myocardial ischemia-reperfusion injury in patients undergoing cardiac valve surgery

The protective effect and mechanism of bilateral thoracic paravertebral nerve block on myocardial protection in patients undergoing open-heart surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300074784
Enrollment
Unknown
Registered
2023-08-16
Start date
2023-08-18
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

myocardial ischemia reperfusion injury

Interventions

TPVB group:Ultrasound-guided bilateral paravertabral block
group GA:None

Sponsors

Department of Anesthesiology, Xiangya Second Hospital, Central South University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Patients undergoing cardiac surgery via sternotomy; 2.Aged 18~65 years; 3.ASA II~III; 4.NYHA II~IV.

Exclusion criteria

Exclusion criteria: 1.Emergency surgery; 2.Local anesthetic allergy; 3.Patients with moderate or above Pulmonary hypertension, heart failure (preoperative Ejection fraction<30%), liver and kidney dysfunction, and receiving steroid hormone, dopamine, Sodium nitroprusside or Nitroglycerin ; 4.Severe mental disease or cognitive impairment.

Design outcomes

Primary

MeasureTime frame
cTnI;—

Secondary

MeasureTime frame
CK-MB;lactate dehydrogenase;Postoperative cardiac function;Perioperative blood pressure;mean arterial pressure;—

Countries

China

Contacts

Public ContactXu Junmei

Xiangya Second Hospital of Central South University

13975148864@139.com+86 139 7514 8864

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026