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Effect of different administration modes of dexmedetomidine combined with quadratus lumborum block on postoperative analgesia in retroperitoneoscopic surgery: a prospective, randomized controlled trial

Effect of different administration modes of dexmedetomidine combined with quadratus lumborum block on postoperative analgesia in retroperitoneoscopic surgery: a prospective, randomized controlled trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300074778
Enrollment
Unknown
Registered
2023-08-16
Start date
2023-08-20
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retroperitoneoscopic Surgery

Interventions

Group R:Patients in group R received quadratus lumborum block with 0.375% ropivacaine 30 ml and were infused with 50 ml of saline.
Group RD:Patients in group RD received quadratus lumborum block with 1 µg/kg dexmedetomidine combined with 0.375% ropivacaine 30 ml and were infused with 50 ml of saline.
Group RDiv:Patients in group RDiv received quadratus lumborum block with 0.375% ropivacaine 30 ml and were infused with 1 µg/kg of dexmedetomidine mixed with 50 ml of saline

Sponsors

Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age 18~75 years old; 2. ASA I-III level; 3. BMI 18.5~30.0 kg/m2

Exclusion criteria

Exclusion criteria: 1. contraindications of regional nerve block, such as local infection at the puncture site or severe coagulation disorders; 2. allergies to any drugs used in this trial; 3. severe preoperative complications, such as cardiovascular and cerebrovascular diseases, respiratory diseases, abnormal function of liver and kidney, or diabetes; 4. history of chronic pain; long-term opioid, hormones or non-steroidal drugs therapy; 5. inability to communicate normally, including hearing impairment, language comprehension impairment, mental illness, etc.; 6. bradycardia; 7. involvement in other studies.

Design outcomes

Primary

MeasureTime frame
duration of analgesia;

Secondary

MeasureTime frame
VAS scores;mean arterial pressure;heart rate;intraoperative consumption of propofol;intraoperative consumption of remifentanil;effective pressing times of PCIA;the consumption of sufentanil of PCIA;the number of patients with remedial anagesia;QoR-15 scores;postoperative adverse reactions;

Countries

China

Contacts

Public ContactZhao Linlin

Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University

lin1675@163.com+86 181 6877 7313

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 20, 2026