Osteoarthritis of the knee
Conditions
Interventions
Group A:Preoperative adductor canal block
Group B:Postoperative adductor canal block
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients requiring initial unilateral TKA surgery due to severe osteoarthritis of the knee; (2) Age 18-80 years old; (3) The preoperative American Society of Anesthesiologists (ASA) rating (anesthesia risk assessment) is grade I to III.
Exclusion criteria
Exclusion criteria: (1) Patients with heart, lung and other important organ failure; (2) Abnormal liver and kidney function (ALT, AST> 1.5 times normal value, blood BUN>-8.3 mmoll, blood Scr>115 umol/L); (3) Patients with diabetes and poorly controlled blood glucose levels who are judged by researchers to be at risk of infection; (4) Combined with consciousness disorder or mental illness; (5) Have a history of open knee surgery; (6) Neuromuscular dysfunction affecting lower limb function; (7) Patients with severe coagulation dysfunction; (8) Combined with serious internal and surgical diseases or physical weakness, unable to tolerate surgery; (9) Severely unstable TKA that cannot be cured using ligament-preserving TKA; (10) There is an active infection in the body (systemic or local infectious lesions); (11) Serious osteoporosis, metabolic bone disease, radiation bone disease, and tumor around the knee joint; (12) Women during family planning, lactation and pregnancy during the entire clinical study period; (13) Participants who have participated in other clinical trials within 3 months; (14) Those who are not suitable to participate in the clinical trial due to other reasons; (15) knee flexion deformity =30° or internal and external varus deformity =30°; (16) Those allergic to drugs used in this study; (17) opioid addicts; (18) Language impairment and inability to complete the Visual analogue scale (VAS) of pain.(YNMT)·
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative dosage of remedial morphine hydrochloride; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first postoperative remedial analgesia;VAS pain score;Range of knee motion;Quadriceps strength;Incidence of postoperative complications;Daily walking distance;The duration of hospital stay;Intraoperative inhalation anesthetic dosage;Times of intraoperative hypertension;Intraoperative opioid dosage;Opioid dosage in PACU;Cortisol level in blood after surgery;Adrenocorticotropic hormone level in blood after surgery; | — |
Countries
China
Contacts
Public ContactPengde Kang
West China Hospital, Sichuan University
Outcome results
None listed