undifferentiated connective tissue disease
Conditions
Interventions
Pregnancy group/Pregnancy failure group:None
Sponsors
Gulou Hospital affiliated to Medical College of Nanjing University
Eligibility
Sex/Gender
Female
Age
22 Years to 45 Years
Inclusion criteria
Inclusion criteria: ?Patients with undifferentiated connective tissue disease: clinically have more than one typical CTD symptoms, signs, or bad pregnancy history, with ANA positive (antinuclear antibody detected at two different times = 1:80), but do not meet any of the established diagnostic criteria of CTD; ?Regular use of a stable dose of hydroxychloroquine for more than 3 months; ?The age at study inclusion was <45 years;
Exclusion criteria
Exclusion criteria: ?Patients who take hydroxychloroquine irregularly; ?Patients with miscarriage due to chromosome abnormalities in pregnancy; ?Pregnancy complicated with tumor; ?Patients diagnosed with CTD.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of hydroxychloroquine and its metabolites; | — |
Secondary
| Measure | Time frame |
|---|---|
| ANA;ENA;ESR;APL;CBC;Biochemical Examination;genotype; | — |
Countries
China
Contacts
Public ContactQing Shu
Gulou Hospital affiliated to Medical College of Nanjing University
Outcome results
None listed