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Analysis of the effect of enhanced hypotension on postoperative CT cerebral perfusion in hypertensive intracerebral hemorrhage: a randomized, single blind, case-control study

Analysis of the effect of enhanced hypotension on postoperative CT cerebral perfusion in hypertensive intracerebral hemorrhage: a randomized, single blind, case-control study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300074770
Enrollment
Unknown
Registered
2023-08-16
Start date
2023-08-14
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertensive cerebral hemorrhage

Interventions

Test group:The patients in the enhanced antihypertensive group should control their systolic blood pressure within 1 hour of admission to (120-140mmHg). The patient completed a CT brain perfusion scan
control group:Patients in the conventional antihypertensive group should control their systolic blood pressure within 1 hour of admission to (140-160mmHg). The patient completed a CT brain perfusion s

Sponsors

Yibin Second People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1) Age>18 years old,<70 years old; Has a clear history of hypertension in the past, with an admission blood pressure value of = 160mmHg; 2) Indications for surgical craniotomy that meet the following criteria: basal ganglia and thalamic hemorrhage: ? basal ganglia hematoma exceeding 30ml, temporal lobe hematoma exceeding 20ml; ? Temporal lobe inguinal hernia; ? Imaging shows significant intracranial hypertension (displacement of midline structure exceeding 5 mm; compression and occlusion of ipsilateral ventricle exceeding 1/2; blurring or disappearance of ipsilateral cistern and sulcus); 3) No other serious diseases that seriously affect the patient's prognosis; 4) The first craniotomy was performed on this case, and there is no history of surgery at the site of the surgical approach.

Exclusion criteria

Exclusion criteria: 1) Preoperative dilated pupils, cerebral hernia, and unstable vital signs; 2) Having blood system diseases and long-term oral anticoagulant drug coagulation dysfunction; 3) The postoperative condition continues to worsen, with unstable vital signs and inability to undergo cranial CT examination; 4) Preoperative confirmation of tumor stroke, rupture of cerebral aneurysm, cerebral vascular malformation bleeding, vascular amyloidosis bleeding, etc; 5) Allergic constitution, allergic to contrast agents; 6) Missing visits.

Design outcomes

Primary

MeasureTime frame
Cerebral blood volume;cerebral blood flow;

Secondary

MeasureTime frame
MRS score;Time Density Curve;Vascular surface permeability;

Countries

China

Contacts

Public ContactJiang Jingcheng

Yibin Second People's Hospital

572004258@qq.com+86 182 0821 1825

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026