remimazolam besylate for gastroenteroscopy sedation in patients with confirmed or suspected sleep apnea
Conditions
Interventions
Remimazolam group:Remimazolam was sedated at 0.2-0.3mg/kg
Propofol group:Propofol was sedated at 2-2.5mg/kg
Sponsors
The first affiliated hospital of Fujian Medical University,China.
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ?ASA Grade?~?;?Age 18~65 years old?Patients with suspected sleep apnea ;?Patients underwent agastroenteroscopy sedation under intravenous anesthesia ;?clearly understand and voluntarily participate in the study,signed by the informed consent.
Exclusion criteria
Exclusion criteria: ? Patients with psychiatric and neurological disorders;?People who take psychotropic drugs such as diazepam and anti-anxiety,and those who abuse alcohol or drugs;?Patients with speech,vision or hearing impairments;?Patients who are allergic or contraindicated to benzodiazepines,propofol,remifentanil and their drug components;?Serious cardiac and pulmonary disorders( MET2,cardiacfuction>2,SPO2<92%);?Severe liver((Child-PughC grade or above) and autofunctionimpairment;?Patients with unsatisfactory blood pressure control treated with antihypertensive drugs(sit-systolic blood pressure =180mmHg and diastolic blooc pressure=100mmHg during screening period);?Severe OSAHS requiring CPAP treatment;?Patients with acute respiratory in flammation during asthma attack or 2 weeks and not cured;?Patients who participated in the clinical trial of remimazolam or other drugs foe nearly 3 months; ?Before the preoperative visit had knowm obvious difficult airway(midified Mallampati? grade) and other researchers believed that may affect the safety of patients during the study);?Acute heart failure;unstable angina;myocardial infarction within 6 months before screening;restingcardiogram heart rate<50 beats/min;third degree atrioventricular biock;severe teicuspid valve insufficiency;severe arrhythmia;?Without an escort or guardian;?Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hyoxemia; | — |
Secondary
| Measure | Time frame |
|---|---|
| hypotension;Addotional drug inventory; | — |
Countries
China
Contacts
Public ContactKai Zeng
The first affiliated hospital of Fujian Medical University,China.
Outcome results
None listed