Chronic heart failure
Conditions
Interventions
Conventional treatment group:Other conventional anti chronic heart failure drugs taking non Aldosterone receptor blockers for 4 consecutive weeks
Eprolidone group:Take regular medication and combine with 25 mg/day of Eprolidone, gradually increasing to 50 mg/day, for 4 consecutive weeks.
Sponsors
College of Pharmacy, Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Sign informed consent form, NYHA Level I, Level II ? The left ventricular Ejection fraction (LVEF) measured by radionuclide ventriculography (RNVG) is = 45% after the diagnosis of Grade I chronic congestive heart failure.
Exclusion criteria
Exclusion criteria: Age80, serum creatinine level>2.5 mg/dL, blood potassium level>5.0 mmol/L, surgical treatment of valvular heart disease, Contraindication to the study drug, use of other Aldosterone receptor antagonists, malignant tumors and other life-threatening non heart diseases, legally incapacitated patients, drug and alcohol abuse history, pregnant women and postpartum women, women who breast fed during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treg cell activity in circulation;Formaldehyde solid level in the cycle;The level of inflammatory factors in plasma;Cardiovascular hospitalization; | — |
Secondary
| Measure | Time frame |
|---|---|
| clinical status;Patient quality related to patient health; | — |
Countries
China
Contacts
Public ContactChengLu feng
College of Pharmacy, Xinjiang Medical University
Outcome results
None listed