Elderly surgical patients
Conditions
Interventions
Control group (18-64 years old):Lidocaine 1.5 mg/kg was injected intravenously during anesthesia induction
Experimental group (65-74 years old):Lidocaine 1.5 mg/kg was injected intravenously during anesthesia induction
Experimental group (75-84 years old):Lidocaine 1 mg/kg was injected intravenously during anesthesia induction
Experimental group (=85 years old):Lidocaine 1 mg/kg was injected intravenously during anesthesia induction
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Adult patients aged 18-64 years and patients aged 65-74 years, 75-84 years and older than 85 years; 2.ASA Level I-III; 3.BMI:18.5-24.9 kg/m2; 4. Patients undergoing elective surgery under general anesthesia with tracheal intubation.
Exclusion criteria
Exclusion criteria: 1. Allergic to lidocaine or narcotic drugs; 2. Unable to sign informed consent; 3. Severe hepatic and renal insufficiency; Total bilirubin >1.46mg/dl; Serum creatinine exceeding 2 mg/dL; End-stage liver and kidney disease; 4. Serious heart disease; Severe heart block, sick sinus syndrome, sinus bradycardia, AS syndrome, preexcitation syndrome, etc. 5. Ideal weight (IBW) <40 kg; 6. 2 weeks before the trial or participating in other drug clinical trials; 7. Long-term use of cimetidine, beta blockers and other drugs that affect lidocaine metabolism or aggravate lidocaine adverse reactions; 8. Have a history of epilepsy or mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lidocaine plasma concentration;Plasma concentrations of lidocaine active metabolites;Maximum peak concentration of the drug in plasma (Cmax);Time to reach maximum concentration (Tmax);Terminal elimination half-life (t1/2);Clearance rates;Apparent distribution volume;Area under the curve (AUC) from time zero to infinity;AUC0-t; | — |
Secondary
| Measure | Time frame |
|---|---|
| Single nucleotide polymorphisms of metabolic enzymes CYP1A2 and CYP3A4;Age, gender, height, weight, ideal weight and body mass index;Biochemical indexes such as liver and kidney function before and after operation;Adverse drug reaction; | — |
Countries
China
Contacts
Public ContactFaping Tu
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed