Pyogenic Liver Abscess
Conditions
Interventions
according to the abnormalities of liver function to give the appropriate hepatoprotective treatment
Control goup:Routine treatment, the third generation of cephalosporins or quinolone antibiotics + metronidazole empirical anti-infective treatment after admission, according to the results of drug sen
for the obvious elevation of temperature to give antipyretic symptomatic treatment
blood glucose monitoring, control of fasting glucose at 5.8-9.0 mmol / L, postprandial blood glucose control at 10.0 mmol / L or so appropriate to maintain electrolyte balance and correct acid-base ba
Tounong san group:On the basis of the control group, according to the dialectical treatment, the translucency method was adopted, i.e. the basic formula of translucency pus san (raw astragalus 15 g, a
Sponsors
Jiangsu Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
29 Years to 83 Years
Inclusion criteria
Inclusion criteria: (1) Clinical manifestations characterized by PLA include typical clinical manifestations such as chills, high fever, liver pain, fatigue, and loss of appetite; (2) B-ultrasound, CT or MRI imaging examination showed characteristic manifestations of liver abscess; The diameter of the pus cavity is = 75px, with sufficient liquefaction. (3) Puncture or surgical extraction of pus, confirmed by bacterial culture results; (4) Excluding amoebic liver abscess, tuberculous liver abscess, and liver abscess after liver transplantation; (5) Informed consent, voluntary testing. The process of obtaining informed consent should comply with GCP regulations.
Exclusion criteria
Exclusion criteria: (1) Individuals with severe cardiovascular, cerebrovascular, liver, kidney, and hematopoietic system diseases, as well as mental illness; (2) Individuals with contraindications to ultrasound guided puncture; (3) Critically ill, with a body temperature above 40.0 ?, accompanied by septic shock and multiple organ dysfunction; (4) Multiple liver abscesses or peritonitis caused by abscess rupture requiring surgical intervention; Abscess with a diameter less than 75px, insufficient liquefaction, and regular treatment without the need for puncture and drainage. (5) Individuals who are unable to give full informed consent due to intellectual or behavioral impairments; (6) Allergic constitution, such as those with a history of allergies to two or more drugs or substances, or those known to be allergic to the ingredients of the test drug; (7) Patients participating in clinical trials of other drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abscess diameter;Abscess volume;CD4; | — |
Secondary
| Measure | Time frame |
|---|---|
| TNF-?;IFN-?;IL-8;IL-2; | — |
Countries
China
Contacts
Public Contactzhangyi
Nanjing University of Chinese Medicine
Outcome results
None listed