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Effects of priming transcranial direct current stimulation protocol on promoting upper limb motor recovery and regulating the brain plasticity after stroke: study protocol for a randomized controlled trial

Effects of priming transcranial direct current stimulation protocol on promoting upper limb motor recovery and regulating the brain plasticity after stroke: study protocol for a randomized controlled trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300074681
Enrollment
Unknown
Registered
2023-08-12
Start date
2023-08-14
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

experiment group:The experiment group will receive 20 minutes cathodal tDCS which applied in affected primary motor cortex (M1), followed by 20 minutes anodal tDCS targeting affected M1 combined with
control group:In control group, participants will receive 20 minutes sham cathodal tDCS followed by 20 minutes anodal tDCS applied in lesioned M1 combined with concurrently robot-assisted upper limb t

Sponsors

Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: (1) Have a diagnosis of a subcortical stroke by magnetic resonance imaging or computed tomography; (2) First-ever unilateral ischemic or hemorrhagic stroke; (3) 1 to 6 months after stroke onset; (4) Aged 18-64 years old; (5) With residual upper limb motor dysfunction; (6) A baseline score of the Fugl-Meyer Assessment for Upper Extremity [FMA-UE] of 20 to 50; (7) Able to give written informed consent and complete necessary research assessments and interventions

Exclusion criteria

Exclusion criteria: (1) Vital signs are not stable, or patients with important organ failure; (2) Disturbance of consciousness or cognitive impairments [Mini-Mental State Examination (MMSE) 7) ;(6) Unstable fracture, severe osteoporosis; (7) Taking psychotropic drugs; (8) Neurological disorders other than stroke; (9) Serious heart disease;(10) Pregnant women; (11) Electrode patch severe allergy, local skin injury or inflammation, stimulate the area of hyperalgesia

Design outcomes

Primary

MeasureTime frame
Wolf Motor Function Test;Fugl-Meyer Upper Extremity;

Secondary

MeasureTime frame
The Modified Barthel Index (M;MEP ;The rest state fNIRS;

Countries

China

Contacts

Public ContactBaizhongfei

Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)

bzf567@163.com+86 183 2173 0579

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 7, 2026