Microbiome, lipid, and metabolome effects of labor analgesia on infants' immune inflammation and cognition

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300074679

Enrollment

Unknown

Registered

2023-08-12

Start date

2023-08-12

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

labor analgesia

Interventions

Experimental group :Intraspinal labor analgesia was performed

Control group:No treatment

Eligibility

Sex/Gender

Female

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Age =18 years old 2. Primiparas with singleton pregnancy and natural conception between 37 and 41 +6 gestational weeks 3.first pregnancy, no history of miscarriage or ectopic pregnancy 4.cervical dilation <5 cm, vaginal delivery is planned

Exclusion criteria

Exclusion criteria: 1.Diseases of the immune system, including but not limited to cancer, asthma, rheumatism, lupus erythematosus, history of hyperthyroidism and hypothyroidism, etc 2. pregnancy complicated with intrahepatic cholestasis, serious liver and kidney dysfunction 3. Thrombocytopenia 4. Fetal growth restriction and macrosomia in the second and third trimesters of pregnancy 5. Inflammation and/or infection (chorioamnionitis)

Design outcomes

Primary

Measure	Time frame
Metabolomics of blood;Metabolomics of the placenta;Microbiome ;	—

Countries

China

Contacts

Public ContactMing Liu

Fujian Maternal and Child Health Hospital

buyouyou@qq.com+86 180 6073 6156

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026