Diarrhea
Conditions
Interventions
Gold Standard:Stool cultures for bacteria and fungi
ELISA, PCR or Sanger sequencing for viruses
fecal smear for parasites.
Index test:targeted next generation sequencing(tNGS)
Sponsors
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
10 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) The subjects volunteered to join the study and signed the informed consent; 2) The subjects were diagnosed with hematological diseases; 3) The subjects defecated 3 or more times a day, and has abnormal stool characteristics (loose stool, watery stool, mucus stool, bloody stool, etc.), and the total stool volume exceeded 250g per day.
Exclusion criteria
Exclusion criteria: Subjects will be excluded if they have any of the following conditions: 1) Inability to provide written informed consent; 2) Subjects who received gastrointestinal surgery within the past 3 months; 3) Subjects who were diagnosed with inflammatory bowel disease (ulcerative colitis and Crohn's disease), intestinal malignancies, chronic pancreatitis, or pancreatic cancer; 4) Other concomitant diseases or other reasons that are not suitable for inclusion according to the judgment of the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| targeted next generation sequencing(tNGS) ;Accuracy ;Sensitivity ;Specificity ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stool cultures for bacteria and fungi;Stool gram's stain;Stool viruses detection;fecal smear; | — |
Countries
China
Contacts
Public ContactEllie Jiang
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed