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Changes of intestinal flora in patients with epithelial ovarian cancer treated with PARP inhibitor first-line maintenance therapy: a non-randomized, double-blind, observational cohort study

Changes of intestinal flora in patients with epithelial ovarian cancer treated with PARP inhibitor first-line maintenance therapy: a non-randomized, double-blind, observational cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300074653
Enrollment
Unknown
Registered
2023-08-11
Start date
2023-09-01
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epithelial ovarian cancer

Interventions

Follow-up observation group:no
A drug maintenance treatment group:no
Two kinds of drugs maintenance treatment group:no

Sponsors

The Second Affiliated Hospital of Nanchang University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: ?Women over the age of 18 and having sex; ?Patients with epithelial ovarian cancer diagnosed by pathology; ?Can complete the established initial treatment plan (neoadjuvant chemotherapy + surgery + chemotherapy, surgery + chemotherapy, chemotherapy); ?Can or cannot complete BRCA gene and / or HRD detection; ?Complete remission, partial remission and disease stability were achieved at the completion of the initial treatment; ?Ensure that samples are taken as scheduled before the completion of the initial treatment, at the completion of the initial treatment and at the end of 1, 3, 6 and 12 months after the completion of the initial treatment.

Exclusion criteria

Exclusion criteria: ?A history of oral or intravenous infusion of antibiotics within 2 weeks before sampling; ?Patients with primary malignant tumors of other organs, benign diseases of digestive tract or rectovaginal fistula; ?Initial treatment combined with antineoplastic drugs except paclitaxel and carboplatin

Design outcomes

Primary

MeasureTime frame
16s rRNA sequencing results;Evaluation of therapeutic response in solid tumors;

Secondary

MeasureTime frame
Adverse reactions;

Countries

China

Contacts

Public ContactBuzhen Tan

The Second Affiliated Hospital of Nanchang University

tanbuzhen@sina.com+86 139 7919 1592

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026