acute typeA aortic dissection
Conditions
Interventions
Experimental group:Undergoing cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) to Aortic Arch Replacement and Elephant Stent using a hemoperfusion device (HA380)
Control group:Undergoing cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) to Aortic Arch Replacement and Elephant Stent
Sponsors
Department of Cardiovascular Surgery ,Yan'an Hospital of Kunming City
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged18-75years,regeardless of gender 2.Patients with actue type A aortic dissection, planning to undergo cardiopulmonary bypass and deep hypothermic circulatory arrest to Aortic Arch Replacement and Elephant Stent 3.Onset time=14days 4.Able to understand and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1.Previous history of cardiac surgeries under cardiopulmonary bypass 2. Patients with preoperative hepatic dysfunction: serum aspartate transferase or alanine transferase levels are 5 times higher than normal or hyperbilirubinemia 3.Patients with preoperative renal dysfunction: History of chronic renal dysfunction or glomerular filtration rate = 60ml/min 4.Connective tissue diseases, hematological diseases, oral anticoagulants, antiplatelet drugs 5. Pregnancy 6. Patients who cannot understand the informed consent form or refuse to participate in the experiment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma-free hemoglobin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum creatinine;Aspartate transferase AST;Alanine transferase ALT;Mechanical ventilation time;length of ICU stay;total hospital stay ;c-reactiveprotein,CRP;a period of cardiopulmonary bypass time; | — |
Countries
China
Contacts
Public ContactZhao Wang
Department of Cardiovascular Surgery ,Yan'an Hospital of Kunming City
Outcome results
None listed