Lung tumors
Conditions
Interventions
Remazolam tosylate group:During the anesthesia maintenance period, from the start of skin incision to the end of surgery, continue to pump 0.2mg/kg/h of remazolam tosylate
Dexmedetomidine group:During the anesthesia maintenance period, continue to pump 0.4 ug/kg/h of dexmedetomidine from the start of skin incision to the end of surgery
Sponsors
The First Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ASA grade II.-III., cardiac function I.-II.; Patients who undergo single-lung ventilation with thoracotomy under elective general anesthesia; No obvious cardiovascular, lung, liver, kidney and other important organ diseases, no electrolyte imbalances and infections, no immune and endocrine system diseases; have not taken nonsteroidal anti-inflammatory drugs and hormonal drugs in the near future, and have not received other drug studies in the month before surgery; After pulmonary function training before surgery, lung function is within normal levels; Estimated duration of surgery is 4-6 hours.
Exclusion criteria
Exclusion criteria: Immune, endocrine, neurological and psychiatric disorders before surgery; Severe heart, lung, liver, and kidney dysfunction; narrowing or occlusion of one or both main bronchi due to lung disorders or other diseases; preoperative use of immunosuppressive drugs and nonsteroidal anti-inflammatory drugs; Respiratory and pulmonary infections before surgery; Forced expiratory volume (FEV1) in the first second of preoperative pulmonary function test 30mmHg; Intraoperative oxygen saturation is continuously less than 90%, and airway pressure > 40cmH2O; Intraoperative persistent hypotension or hypertension, mean arterial pressure is less than or above the basal value of 20%, intraoperative blood loss is greater than 1000ml.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Average arterial pressure, heart rate, blood oxygen saturation,Respiratory rate,Aldrete score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sufentanil use, propofol use, operation time, single lung ventilation time, anesthesia recovery room stay;Complications of anesthesia; | — |
Countries
China
Contacts
Public ContactWang Dan
The First Affiliated Hospital of Harbin Medical University
Outcome results
None listed