preterm infants
Conditions
Interventions
group of spontaneous breathing trial:Perform extubation according to the standard for spontaneous breathing test extubation
group of clinical judgment:Perform extubation based on clinical criteria
Sponsors
The Second Hospital of Shandong Universit
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Preterm infants with gestational age of 26+0 weeks to 31+6 weeks, birth weight of 600~1500g, and assisted ventilation by tracheal intubation ventilator within 7 days after birth. (2) Mechanical ventilation time >24 hours. (3) First intubation after birth and never extubation (excluding cases of replacement of tracheal intubation and continuation of mechanical ventilation immediately after accidental extubation).
Exclusion criteria
Exclusion criteria: (1) Congenital genetic metabolic diseases and severe congenital malformations. (2) Neurological and muscular diseases affecting respiratory function (such as central hypopnea syndrome, myasthenia gravis, severe perinatal asphyxia , severe intracranial hemorrhage, etc.). (3) Contraindications for non-invasive ventilator assisted ventilation (such as pneumothorax, diaphragmatic hernia, etc.). (4) Others: children deemed unsuitable for inclusion in the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of extubation failure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of spontaneous breathing trial;duration of spontaneous breathing trial;reasons for failure of spontaneous breathing trial;ventilator mode and parameters before extubation;non-invasive ventilator mode and parameters after extubation;re-intubation time;re-intubation ventilator parameters;non-invasive ventilator use time;re-intubation rate within 7 days;Incidence of air leakage, pneumonia, late-onset sepsis, pulmonary hemorrhage, intracranial hemorrhage, bronchopulmonary dysplasia, retinal disease of preterm infants, necrotizing enterocolitis, etc;Length of stay;Mortality rate;Tracheal intubation ventilator assisted ventilation time; | — |
Countries
China
Contacts
Public ContactJiang Xue
The Second Hospital of Shandong University
Outcome results
None listed