Patients over 65 years of age undergoing spinal surgery under tracheal intubation and general anesthesia
Conditions
Interventions
Esketamine group(K Group):Esketamine and other drugs were used for anesthesia
Saline control group:Saline and other drugs were used for anesthesia,but not Esketamine.
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients over 65 years of age who were scheduled for spinal surgery under general anesthesia with tracheal intubation, with an expected duration of surgery greater than 1 hour, volunteered to participate and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Severe bradycardia (2) patients with contraindications to esmketamine, such as patients with serious risk of elevated blood pressure or intracranial pressure; People with poorly controlled or untreated hypertension (arterial hypertension, resting systolic/diastolic blood pressure > 180/100 mmHg); Pre-eclampsia and eclampsia; People with untreated or under-treated hyperthyroidism (hyperthyroidism) (3) overt ischemic heart disease; Congestive heart failure; Severe liver and kidney dysfunction; Have or have had a history of a serious mental disorder; Increased intracranial pressure and central nervous system injury or disease; Glaucoma; Previous history of alcohol and drug abuse. (4) hearing or language impairment, or inability to cooperate with the neurocognitive assessment for other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate and blood pressure;Use of vasoactive drugs and atropine;RASS sedation score;Recovery room residence time;postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactXiaoxing Chen
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed