essential hypertension
Conditions
Interventions
treatment group: Xiantianma Capsule+Amlodipine Benzenesulfonate Tablets
control group: Xiantianma Capsule placebo+Amlodipine Benzenesulfonate Tablets
Sponsors
Guang 'anmen Hospital, Chinese Academy of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
25 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) The diagnosis of western medicine conforms to the diagnostic criteria of middle and low risk essential hypertension (grade 1-2); (2) A cardiovascular specialist with an associate senior professional title judged that it meets the diagnostic criteria of hyperactivity of liver yang; (3) Hypertension has not been treated or stopped using antihypertensive drugs for at least 2 weeks; (4) Age between 25 and 75, regardless of sex; (5) Patients voluntarily participate in the trial and sign the informed consent form, which has a high degree of obedience and cooperation.
Exclusion criteria
Exclusion criteria: (1) secondary hypertension; (2)The acute coronary syndrome, heart failure, serious arrhythmia, valvular heart disease, cardiomyopathy, stroke and other serious cardiovascular and cerebrovascular diseases; (3) Diabetes patients (fasting blood glucose > 11mmol /L), or diabetes-related complications (such as nephropathy or peripheral neuropathy); (4) taking beta blockers or sedative sleeping pills; (5) Shift workers; (6) Abnormal liver function [(alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are more than 3 times the normal upper limit)], or severe abnormal renal function (estimated glomerular filtration rate < 30 ml/(min/1.73 m2); (7) Suffering from serious mental disorder, intellectual disorder or language disorder; Suffering from serious hematopoietic diseases; People with malignant tumors; (8)Being allergic to Chinese and western medicines in this study; (9) Patients during pregnancy and lactation; (10) Those who have participated in clinical trials of other drugs at the same time or in recent 2 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic pressure in clinic; | — |
Secondary
| Measure | Time frame |
|---|---|
| Diastolic blood pressure and blood pressure control rate in consultation room;Ambulatory blood pressure monitoring;Integrals of TCM syndromes;Hypertension symptom score;Headache visual analogue scale;Sleep quality;quality of life;Anxiety and depression;Blood lipid and biochemical indexes; | — |
Countries
China
Contacts
Public ContactKuiwu Yao
Guang 'anmen Hospital, Chinese Academy of Traditional Chinese Medicine
Outcome results
None listed