Helicobacter pylori infection
Conditions
Interventions
First treatment - control group:Venora raw 20mg, PO, 30min bid before breakfast dinner
Colloidal bismuth pectin 300mg, PO, 30min bid before breakfast and dinner
Amoxicillin 1000mg, PO, 30min bid after breakfast and dinner
Clarithromycin 500mg, PO, 30min bid after breakfast and dinner
First treatment - trial group:Venora raw 20mg, PO, 30min bid before breakfast dinner
Minocycline 100mg, PO, 30min bid after breakfast and dinner
Remedial treatment - control group:Venora raw 20mg, PO, 30min bid before breakfast dinner
Furazolidone 100mg, PO, 30min bid after breakfast and dinner
Remedial Treatment - Trial group:Venora raw 20mg, PO, 30min bid before breakfast dinner
Colloidal bismuth pectin 300mg, PO, 30min before breakfast, lunch and dinner bid
Sponsors
Huai 'an Fifth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-70 years old, gender is not limited; (2) Gastric mucosal tissue staining, rapid urease test, 13C/14C urea breath test or stool Hp antigen any positive confirmed Hp infection; (3) Those who have eradicated Hp for the first time or failed to eradicate Hp in the past, and have not been treated with sterilization within half a year; (4) have used the above scheme in the past, and failed; (5) Agree to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Gastric ulcer, gastric cancer and other major stomach diseases are excluded; (2) No H2 receptor antagonist (H2RA), proton pump inhibitor (PPI) or potassium competitive acid blocker (P-CAB) has been used in the past 2 weeks; No bismuth, antibiotics (including Chinese medicines with antibacterial effects) or probiotics have been used in the past 4 weeks; (3) Pregnant or lactating women; (4) There are other serious diseases that affect the evaluation of this study, such as serious liver, kidney, cardiovascular diseases, malignant tumors and alcoholism; (5) Patients who are allergic to the drugs used in this study, or have a history of penicillin allergy; (6) Participants who had participated in other clinical trials within 3 months before enrollment; (7) can not correctly express their symptoms and wishes, such as mental illness, severe neurosis, can not cooperate with this test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hp eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient compliance;Incidence of adverse reactions;Improvement of PGI, PGII and gastrin 17; | — |
Countries
China
Contacts
Public ContactYang Weixuan
Huai 'an Fifth People's Hospital
Outcome results
None listed