stroke
Conditions
Interventions
Intelligent Rehabilitation Group:Applying the precise intervention paradigm of active induction Neuroplasticity proposed in this project
traditional rehabilitation group:Bobath,CIMT, and FES
Sponsors
China research rehabilitation center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients or surrogates signed informed consent; first-onset ischemic stroke confirmed by imaging (based on MRI) ; course =3 months; age range 18-80 years; With moderate to severe upper extremity and hand dysfunction (upper extremity and hand Brunnstrom rating =4) ; upper extremity flexor muscle tension Ashworth rating =2; sitting balance rating =2; ability to perform 3 simple verbal commands; and ability to perform 3 tasks Corrected visual acuity =0.5 in at least one eye; able to follow all research procedures, participate in all treatments and assessments.
Exclusion criteria
Exclusion criteria: Contraindications to MRI (e.g. iron in the body, or artificial pacemaker) ; Major depression (HAMD depression rating scale > 17, geriatric depression rating scale > 10) , Severe cognitive impairment (EG: Montreal Cognitive Assessment <22) ; comorbidity with severe neurological or psychiatric disorders (including dementia, Parkinson's disease, etc.) in addition to stroke; comorbidity with severe medical conditions affecting patients throughout the trial (including, but not limited to, advanced chronic obstructive pulmonary disease, kidney failure and advanced heart failure) ; Other diseases (including but not limited to severe arthritis, Dupuytren contracture, amputation of =2 sites, etc.) that affect the functional recovery of the upper limbs of the stroke-affected side, have communication deficits and affect the participation of the study; Patients who received botulinum toxin injections to the extremities within the last 6 months; were unable or unwilling to undergo the study procedure or treatment, or patients do not meet the study procedure; life expectancy < 6 months; pregnancy; Taking part in another exploratory treatment study; speaking difficult dialects or other languages: because the Montreal Assessment (MOCA) scale is difficult to interpret for aphasia patients, exclusion criteria (MOCA score =22) could be determined by the lead investigator on a case-by-case basis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA;Motor function test; | — |
Secondary
| Measure | Time frame |
|---|---|
| NSE?GFAP; | — |
Countries
China
Contacts
Public ContactLi Bingjie
China Rehabilitation Research Center
Outcome results
None listed