post stroke aphasia
Conditions
Interventions
iTBS group:Patients were treated with intermittent burst theta stimulation (iTBS) for a total of 1800 pulses over 3 consecutive sessions of approximately 10 minutes, for a total of 15 sessions.
sham stimulation group:The targets, parameters, dose and duration of treatment in the sham stimulation group were consistent with those in the iTBS group.
Sponsors
Beijing Bo'ai Hospital, China Rehabilitation Research Center
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: ? Patients with cerebral hemorrhage or cerebral infarction with a disease duration between 1-12 months who meet the diagnostic criteria of the 2018 edition of Chinese Guidelines for Diagnosis and Treatment of Acute Ischemic Stroke or the 2019 edition of Chinese Guidelines for Diagnosis and Treatment of Cerebral Hemorrhage formulated by the Neurology Branch of the Chinese Medical Association and confirmed by cranial CT or MRI ? The patients were assessed as having aphasia according to the Chinese version of the Western Aphasia Battery (WAB), and the WAB aphasia quotient was less than 93.8 points ? Patients were between 18 and 75 years of age (both 18 and 75 years) ? Normal language function before the onset of the disease, and the mother tongue is Chinese, elementary school education or above (with more than 6 years of education) ? Understand the test and sign the informed consent form.
Exclusion criteria
Exclusion criteria: ?Aphasia caused by brain tumor, Parkinson's syndrome, motor neuron disease, traumatic brain injury or other diseases; ? Contraindications to TMS treatment such as pacemakers, cochlear implants, or other metallic foreign bodies and any electronic devices implanted in the body; ? Combined history of epilepsy (presence of at least 2 unprovoked seizures at intervals of more than 24h, or diagnosis of epilepsy syndrome, or seizures within the last 12 months); ? Patients with severe cardiac, pulmonary, hepatic, renal, and other systemic diseases that cannot be controlled by conventional medication, as detected by laboratory tests and examinations; ? Presence of a history of comorbid alcohol, drug, and other abuse; ? The existence of other examination abnormalities investigator judgment is not suitable to participate in this trial patients; ? Women of childbearing age who are pregnant or planning to become pregnant; ?Women of childbearing age who are pregnant or planning to become pregnant; (viii) Patients who are participating in other clinical research trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Aphasia Battery; | — |
Secondary
| Measure | Time frame |
|---|---|
| event-related potential;national institutes of health stroke scale;SAQOL-39;neurotransmitter;brain-derived neurotrophic factor,BDNF; | — |
Countries
China
Contacts
Public ContactLei Shan
Beijing Bo'ai Hospital, China Rehabilitation Research Center
Outcome results
None listed