thyroid surgery
Conditions
Interventions
Dexmedetomidine group (group D: dexmedetomidine 1µg/kg):After induction of general anesthesia for 3 min, the corresponding test drugs were diluted to 5ml, and then sprayed to the tracheal mucosa and g
Lidocaine group (group L: lidocaine 60mg):After induction of general anesthesia for 3 min, the corresponding test drugs were diluted to 5ml, and then sprayed to the tracheal mucosa and glottis by a di
Dexmedetomidine+lidocaine group (group DL: Dexmedetomidine 1µg/kg+lidocaine 60mg):After induction of general anesthesia for 3 min, the corresponding test drugs were diluted to 5ml, and then sprayed to
Saline group (group s):After induction of general anesthesia for 3 min, the corresponding test drugs were diluted to 5ml, and then sprayed to the tracheal mucosa and glottis by a disposable laryngeal
Sponsors
Second Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? American Society of Anesthesiology(ASA)I-II ? Mallampati grade I-II of airway. ? Age is 20-65 years old. ? Patients who plan to undergo thyroid surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: ?ASA=III; ? Body mass index (BMI) = 30kg/m-2; ? Severe cardiovascular, liver and renal dysfunction; Visual or hearing impairment; ? History of concealed airway or maxillofacial and neck surgery; ? Chronic use of opioids or sedatives; ? Chronic respiratory diseases; Recent respiratory tract infection; Chronic cough; ? The anesthesia time exceeds 4 hours; ? After the operation, the extubation time was more than 1 hour; ?Transfer to intensive care unit while still intubated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and classification of postoperative sore throat;Incidence and classification of postoperative hoarseness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic index;Duration of anesthesia, intubation and operation.;Fluid intake and output and The doses of all other medications used during surgery;Incidence of postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactZhaoyang Xiao
Second Affiliated Hospital of Dalian Medical University
Outcome results
None listed