Hysteroscopic surgery
Conditions
Interventions
SK0.1 group:0.1mg/kg Esketamine combined with propofol intravenous infusion
SK0.2 group:0.2mg/kg Esketamine combined with propofol intravenous infusion
SK0.3 group:0.3mg/kg Esketamine combined with propofol intravenous infusion
Sponsors
Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA Level I-II; 2. Age range from 18 to 65 years old; 3. BMI 18-28 Kg/m2; 4. Patients who plan to undergo painless hysteroscopic surgery on a scheduled date; 5. Patients who have signed an anesthesia consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with mental illness; 2. Take opioid or non steroidal drugs 48 hours before surgery; 3. Congenital malformations of the uterus or cervical canal, severe cervical stenosis, and adhesions in the uterine cavity make it difficult to perform hysteroscopy; 4. Allergies to the investigational drug ketamine or propofol; 5. Patients with severe heart disease; Patients with severe hypertension; Patients with intracranial masses and intracranial hypertension; Patients with glaucoma and hyperthyroidism; 6. Patients with severe respiratory diseases; 7. Patients with liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EC50 and EC95 of propofol for each group.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of consciousness disappearance;Wake-up time;recovery time;Satisfaction;Dosage of propofol;SAS Anxiety Scale Score;SDS Depression Scale Score; | — |
Countries
China
Contacts
Public ContactFangjun Wang
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed